Schwerpunkte

  • Kopf- und Gesichtsschmerz
  • Migräne
  • Chronische Migräne
  • Spannungskopfschmerz
  • Clusterkopfschmerz
  • Kopfschmerz nach Verletzungen, Infektionen und Operationen

Beruflicher Werdegang

1961

geboren in Mülheim/Ruhr

1982 - 1988

Studium Humanmedizin, Klinikum Biederstein, Technische Universität, München

Dez. 1989

Promotion

Dez. 1990

Ärztliche Approbation

Mai 1989 - April 1991

Arzt im Praktikum in der Neurologischen Praxis Dr. Pfaffenrath & Dr. Reiter, München

Mai 1991 - Dez. 1992

Post-Doc Fellowship - IHS-Fellowship 1992, Neurophysiologisches Labor, (Prof. JW Lance & Prof. PJ Goadsby), Prince Henry Hospital, Sydney, Australien

Facharztausbildung

Feb. 1993 - Sept. 1995 in der Klinik und Poliklinik für Neurologie, Director: Prof. HC Diener, Universitätsklinik Essen

Okt. 1995 - Sept. 1996 in der Klinik für Psychiatrie und Psychotherapie, Rheinische Kliniken, Landschaftsverband Rheinland; Direktor: (Prof. M Gastpar)

Okt. 1996 - April 1999 in der Klinik und Poliklinik für Neurologie, Director: Prof. HC Diener, Universitätsklinik Essen

12.08.1998

Facharztprüfung Neurologie

Mai 1999 - Okt. 2006

Honorary Consultant & Senior Lecturer: Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, UK

01.11.2006 - 31.03.2007

Chair of Neurology: Division of Clinical Neurosciences, School of Medicine, Southampton University and Southampton General Hospital, Southampton, UK

01.04.2007 - 31.12.2010

W3-Professur für Schmerz & Kopfschmerzforschung: Abteilung für Neurologie und Neurophysiologie, Uniklinik Freiburg und Ärztlicher Leiter im Interdisziplinären Schmerzzentrum, Uniklinik Freiburg

seit Januar 2011

Niedergelassener Neurologe in der Gemeinschaftspraxis Neurologie & Kopfschmerzzentrum Münchner Freiheit

seit 01.09.2011

Chefarzt, Kollegialer Leiter des Algesiologikums - Zentrum für Schmerzmedizin, Schwabing, Clinic Dr. Decker GmbH

Dr. Holger Kaube

Dr. Holger Kaube

Mitgliedschaften und weitere Positionen


  • Ehrenmitglied der British Neuropsychiatry Association
  • International Headache Society (IHS)
  • Deutsche Migräne- und Kopfschmerzgesellschaft (DMKG)
  • Berufsverband der Schmerztherapeuten Deutschland (BVSD)

Advisory Board, Berater und Fortbildungen

  • Merck, Sharp & Dohme (Deutschland), Boston Scientific (Europe), Medtronic (Europe), St. Jude Medical (Europe), Pfizer Pharma (Deutschland), Berlin Chemie, Boehringer Ingelheim Pharma (Deutschland)
  • Ehrenmitglied und wissenschaftlicher Beirat der Clusterkopfschmerz- Selbsthilfegruppen e.V.

 

Erfahrungen als Klinischer Prüfarzt

Teilnahme als Prüfarzt an mehr als 15 Studien in Phasen 1, 2 und 3 mit kommerziellen pharmazeutischen Sponsor und 7 "Investigator initiated" Studien

Indikationen Migräne Akutbehandlung, menstruelle Migräneprophylaxe, Migräneaura-Behandlung, Migräneprophylaxe, Spannungskopfschmerzprophylaxe, Clusterkopfschmerz-Kurzprävention, Schmerzmittelentzugstherapie, Guillain-Barre-Syndrom, akute Lumbago, Schlafstörungen

Veröffentlichungen (90 Publikationen, 2 Publikationen in Nature Medicine und Science)

1. Wolter T, Kaube H. Spinal cord stimulation in cluster headache. Curr Pain Headache Rep. 2013 May;17(5):324. doi: 10.1007/s11916-013-0324-0. PMID: 23504520 [PubMed - in process] 

2. Gantenbein AR, Sandor PS, Fritschy J, Turner R, Goadsby PJ, Kaube H. Sensory information processing may be neuroenergetically more demanding in migraine patients. Neuroreport. 2013 Mar 6;24(4):202-5. doi: 10.1097/WNR.0b013e32835eba81. PMID: 23381352 [PubMed - indexed for MEDLINE] 

3. Afridi SK, Giffin NJ, Kaube H, Goadsby PJ. A randomized controlled Trial of intranasal ketamine in migraine with prolonged aura. Neurology. 2013 Feb. 12; 80(7): 642-7. Epub 2013 Jan 30

4. Hornyak M, Kaube H. Long-Term treatment of a patient with severe restless legs syndrome using intrathecal morphine. Neurology. 2012 Dec 11;79(24):2361-2. doi: 10.1212/WNL.0b013e318278b5e7. Epub 2012 Nov 28. PMID: 23197746 [PubMed - indexed for MEDLINE] 

5. Holle D, Zillessen S, Gaul C, Naegel S, Kaube H, Diener HC, Katsarava Z, Obermann M. Habituation oft he nociceptive blink reflex in episodic and chronic cluster headache. Cephalalgia. 2012 Oct;32(13):998-1004. Epub 2012 Jul 17. PMID: 22807570 [PubMed - indexed for MEDLINE] 

6. Wolter T, Kaube H. Neurostimulation for chronic cluster headache. Ther Adv Neurol Disord. 2012 May;5(3):175-80. doi: 10.1177/1756285612443300. PMID: 22590481 [PubMed] 

7. Färkkilä M, Diener HC, Geraud G, Lainez M, Schoenen J, Harner N, Pilgrim A, Reuter U; COL MIG-202 study group. Efficacy and tolerability of lasmiditan, an oral 5-HT (1F) receptor agonist, for the acute treatment of migraine: a phase 2 randomised, placebo-controlled, parallel-group, dose-ranging study. Lancet Neurol. 2012 May; 11(5): 405-13. Doi: 10.1016/S1474-4422(12)70047-9. Epub 2012 Mar 28. PMID: 22459549 {PubMed-indexed for MEDLINE]

8. Schmidt S, Naranjo JR, Brenneisen C, Gundlach J, Schultz C, Kaube H, Hinterberger T, Jeanmonod D. Pain ratings, psychological functioning and quantitative EEG in a controlled study of chronic back pain patients. PLoS One. 2012;7(3):e31138. doi: 10.1371/journal.pone.0031138. Epub 2012 Mar 14. PMID: 22431961 [PubMed - indexed for MEDLINE] 

9. Holle D, Gaul C, Zillessen S, Naegel S, Krebs S, Diener HC, Kaube H, Katsarava Z, Obermann M. Lateralized central facilitation of trigeminal nociception in cluster headache. Neurology. 2012 Mar 27;78(13):985-92. doi: 12/WNL.0b013e31824d58ce. Epub 2012 Mar 14. PMID: 22422891 [PubMed - indexed for MEDLINE] 

10. Reinhard M, Schork J, Allignol A, Weiller C, Kaube H. Cerebellar and cerebral autoregulation in migraine. Stroke. 2012 Apr;43(4):987-93. doi: /STROKEAHA. 111.644674. Epub 2012 Feb 16. PMID: 22343638 [PubMed - indexed for MEDLINE] 

11. Wolter T, Kiemen A, Porzelius C, Kaube H. Effects of sub-perception threshold spinal cord stimulation in neuropathic pain: a randomized controlled double-blind crossover study. Eur J Pain. 2012 May;16(5):648-55. doi: 10.1002/j.1532-2149.2011.00060.x. Epub 2011 Dec 19. PMID: 22337509 [PubMed - indexed for MEDLINE] 

12. Holle D, Gaul C, Krebs S, Naegel S, Diener HC, Kaube H, Katsarava Z, Obermann M. Nociceptive blink reflex and pain-related evoked potentials in hypnic headache. Cephalalgia. 2011 Aug;31(11):1181-8. doi: 10.1177/0333102411412629. Epub 2011 Jul 15. PMID: 21765149 [PubMed - indexed for MEDLINE] 

13. Wolter T, Kiemen A, Kaube H. High cervical spinal cord stimulation for chronic cluster headache. Cephalagia. 2011 Aug; 31 (11): 1170-80. Epub 2011 Jun 23

14. Weatherall MW, Telzerow AJ, Cittadini E, Kaube H, Goadsby PJ. Intravenous aspirin (Lysine acetylsalicylate) in the inpatient management headache. Neurology. 2010 Sep 21;75(12):1098-103. doi: 10.1212/WNL.0b013e3181f39a11. PMID: 20855853 [PubMed - indexed for MEDLINE] 

15. Mueller D, Obermann M, Koeppen S, Kavuk I, Yoon MS, Sack F, Diener HC, Kaube H, Katsarava Z. Electrically evoked nociceptive potentials for early detection of diabetic small-fiber neuropathy. Eur J Neurol. 2010 Jun 1;17(6):834-41. doi: 10.1111/j.1468-1331.2009.02938.x. Epub 2010 Feb 23. PMID: 20192984 [PubMed - indexed for MEDLINE] 

16. Obermann M, Pleger B, de Greiff A, Stude P, Kaube H, Diener HC, Katsarava Z. Temporal summation of trigeminal pain in human anterior cingulate cortex. Neuroimage. 2009 May 15;46(1):193-200. doi: 10.1016/j.neuroimage.2009.01.038. Epub 2009 Feb 3. PMID: 19457385 [PubMed - indexed for MEDLINE] 

17. Wolter, T., Kaube, H., Mohadjer M. High cervical epidural neurostimulation for cluster headache: case report and review of the literature. Cephalalgia. 2008 (22)

18. Artemenko, A.R., et al., Effects of topiramate on migraine frequency and cortical excitability in patients with frequent migraine. Cephalalgia, 2008. 28(3): p. 203-8.

19. Obermann, M., et al., Impaired trigeminal nociceptive processing in patients with trigeminal neuralgia. Neurology, 2007. 69(9): p. 835-41.

20. Obermann, M., et al., Correlation of epidermal nerve fiber density with pain-related evoked potentials in HIV neuropathy. Pain, 2007.

21. Magis, D., et al., Evaluation and proposal for optimization of neurophysiological tests in migraine: part 2--neuroimaging and the nitroglycerin test. Cephalalgia, 2007. 27(12): p. 1339-59.

22. Magis, D., et al., Evaluation and proposal for optimalization of neurophysiological tests in migraine: part 1--electrophysiological tests. Cephalalgia, 2007. 27(12): p. 1323-38.

23. Dzagnidze, A., et al., Repair capacity for platinum-DNA adducts determines the severity of cisplatin-induced peripheral neuropathy. J Neurosci, 2007. 27(35): p. 9451-7.

24. Busch, V., et al., Sumatriptan and corneal reflexes in headache-free migraine patients: a randomized and placebo-controlled crossover study. Cephalalgia, 2007. 27(2): p. 165-72.

25. Busch, V., et al., Occipital nerve blockade in chronic cluster headache patients and functional connectivity between trigeminal and occipital nerves. Cephalalgia, 2007. 27(11): p. 1206-14.

26. Sandor, P.S., et al., Prosopagnosia as symptom of migraine with aura: a case report. Cephalalgia, 2006. 26(3): p. 345-8.

27. Sandor, P.S., et al., Onset of cluster headache triggered by emotional effect: a case report. J Neurol Neurosurg Psychiatry, 2006. 77(9): p. 1097-9.

28. Rejdak, K., et al., Increased urinary excretion of nitric oxide metabolites in longitudinally monitored migraine patients. Eur J Neurol, 2006. 13(12): p. 1346-51.

29. Paemeleire, K., et al., Practical management of medication-overuse headache. Acta Neurol Belg, 2006. 106(2): p. 43-51.

30. Katsarava, Z., et al., Pain related potentials by electrical stimulation of skin for detection of small-fiber neuropathy in HIV. J Neurol, 2006. 253(12): p. 1581-4.

31. Katsarava, Z., et al., A novel method of eliciting pain-related potentials by transcutaneous electrical stimulation. Headache, 2006. 46(10): p. 1511-7.

32. Busch, V., et al., Functional connectivity between trigeminal and occipital nerves revealed by occipital nerve blockade and nociceptive blink reflexes. Cephalalgia, 2006. 26(1): p. 50-5.

33. Baad-Hansen, L., et al., Blink reflexes in patients with atypical odontalgia and matched healthy controls. Exp Brain Res, 2006. 172(4): p. 498-506.

34. Ayzenberg, I., et al., Central sensitization of the trigeminal and somatic nociceptive systems in medication overuse headache mainly involves cerebral supraspinal structures. Cephalalgia, 2006. 26(9): p. 1106-14.

35. Afridi, S.K., et al., A PET study exploring the laterality of brainstem activation in migraine using glyceryl trinitrate. Brain, 2005. 128(Pt 4): p. 932-9.

36. Afridi, S.K., et al., A positron emission tomographic study in spontaneous migraine. Arch Neurol, 2005. 62(8): p. 1270-5.

37. Afridi, S., H. Kaube, and P.J. Goadsby, Occipital activation in glyceryl trinitrate induced migraine with visual aura. J Neurol Neurosurg Psychiatry, 2005. 76(8): p. 1158-60.

38. Singer, T., et al., Empathy for pain involves the affective but not sensory components of pain. Science, 2004. 303(5661): p. 1157-62.

39. Katsarava, Z., et al., Differences of anti-nociceptive mechanisms of migraine drugs on the trigeminal pain processing during and outside acute migraine attacks. Cephalalgia, 2004. 24(8): p. 657-62.

40. Gil-Gouveia, R., P.A. Wilkinson, and H. Kaube, Severe hemiplegic migraine attack precipitated by fentanyl sedation for esophagogastroscopy. Neurology, 2004. 63(12): p. 2446-7.

41. Giffin, N.J., et al., The effect of multiple stimuli on the modulation of the 'nociceptive' blink reflex. Pain, 2004. 108(1-2): p. 124-8.

42. Cohen, A.S. and H. Kaube, Rare nocturnal headaches. Curr Opin Neurol, 2004. 17(3): p. 295-9.

43. Akerman, S., H. Kaube, and P.J. Goadsby, Anandamide is able to inhibit trigeminal neurons using an in vivo model of trigeminovascular-mediated nociception. J Pharmacol Exp Ther, 2004. 309(1): p. 56-63.

44. Akerman, S., H. Kaube, and P.J. Goadsby, Anandamide acts as a vasodilator of dural blood vessels in vivo by activating TRPV1 receptors. Br J Pharmacol, 2004. 142(8): p. 1354-60.

45. Afridi, S.K., H. Kaube, and P.J. Goadsby, Glyceryl trinitrate triggers premonitory symptoms in migraineurs. Pain, 2004. 110(3): p. 675-80.

46. Kowacs, F., et al., Nociceptive-specific blink reflex and glyceryl trinitrate infusion in healthy volunteers. Eur J Neurol, 2003. 10(3): p. 295-9.

47. Katsarava, Z., et al., Abnormal habituation of 'nociceptive' blink reflex in migraine--evidence for increased excitability of trigeminal nociception. Cephalalgia, 2003. 23(8): p. 814-9.

48. Katsarava, Z., et al., Symptomatic migraine and sensitization of trigeminal nociception associated with contralateral pontine cavernoma. Pain, 2003. 105(1-2): p. 381-4.

49. Giffin, N.J., et al., Effect of the adenosine A1 receptor agonist GR79236 on trigeminal nociception with blink reflex recordings in healthy human subjects. Cephalalgia, 2003. 23(4): p. 287-92.

50. Akerman, S., H. Kaube, and P.J. Goadsby, Vanilloid type 1 receptors (VR1) on trigeminal sensory nerve fibres play a minor role in neurogenic dural vasodilatation, and are involved in capsaicin-induced dural dilation. Br J Pharmacol, 2003. 140(4): p. 718-24.

51. Afridi, S. and H. Kaube, Prophylactic Therapy for Migraine. Curr Treat Options Neurol, 2003. 5(6): p. 431-440.

52. Knight, Y.E., et al., P/Q-type calcium-channel blockade in the periaqueductal gray facilitates trigeminal nociception: a functional genetic link for migraine? J Neurosci, 2002. 22(5): p. RC213.

53. Kaube, H., et al., Acute migraine headache: possible sensitization of neurons in the spinal trigeminal nucleus? Neurology, 2002. 58(8): p. 1234-8.

54. Katsarava, Z., et al., Sensitization of trigeminal nociception specific for migraine but not pain of sinusitis. Neurology, 2002. 59(9): p. 1450-3.

55. Katsarava, Z., et al., Selective damage of trigeminal Adelta fibres in Raeder's syndrome following dissection of the ICA detected by a nociceptive blink reflex. Cephalalgia, 2002. 22(2): p. 151-3.

56. Katsarava, Z., et al., Optimized stimulation and recording parameters of human 'nociception specific' blink reflex recordings. Clin Neurophysiol, 2002. 113(12): p. 1932-6.

57. Giffin, N.J. and H. Kaube, The electrophysiology of migraine. Curr Opin Neurol, 2002. 15(3): p. 303-9.

58. Akerman, S., et al., Nitric oxide synthase inhibitors can antagonize neurogenic and calcitonin gene-related peptide induced dilation of dural meningeal vessels. Br J Pharmacol, 2002. 137(1): p. 62-8.

59. Akerman, S., et al., The effect of anti-migraine compounds on nitric oxide-induced dilation of dural meningeal vessels. Eur J Pharmacol, 2002. 452(2): p. 223-8.

60. Akerman, S., et al., The role of histamine in dural vessel dilation. Brain Res, 2002. 956(1): p. 96-102.

61. Ellrich, J., et al., Is the R3 component of the human blink reflex nociceptive in origin? Pain, 2001. 91(3): p. 389-95.

62. Kaube, H., P. Mummel, and S. Koeppen, Ethambutol related headache in HIV infection: sensitisation to normal CSF pressure? A case report. J Neurol Neurosurg Psychiatry, 2000. 68(4): p. 535-6.

63. Kaube, H., et al., A new method to increase nociception specificity of the human blink reflex. Clin Neurophysiol, 2000. 111(3): p. 413-6.

64. Kaube, H., et al., Aura in some patients with familial hemiplegic migraine can be stopped by intranasal ketamine. Neurology, 2000. 55(1): p. 139-41.

65. Diener, H.C., H. Kaube, and V. Limmroth, [Migraine: clinical aspects, diagnosis and pharmacotherapy]. Internist (Berl), 2000. 41(4): p. 390-8.

66. Kaube, H., et al., Vasodilator agents and supracollicular transection fail to inhibit cortical spreading depression in the cat. Cephalalgia, 1999. 19(6): p. 592-7.

67. Diener, H.C., H. Kaube, and V. Limmroth, Antimigraine drugs. J Neurol, 1999. 246(7): p. 515-9.

68. Diener, H.C., H. Kaube, and V. Limmroth, [Migraine. Symptoms, diagnosis and drug therapy]. Anaesthesist, 1999. 48(11): p. 845-56.

69. Scherbaum, N., et al., Alternative strategies of opiate detoxification: evaluation of the so-called ultra-rapid detoxification. Pharmacopsychiatry, 1998. 31(6): p. 205-9.

70. May, A., et al., Experimental cranial pain elicited by capsaicin: a PET study. Pain, 1998. 74(1): p. 61-6.

71. Diener, H.C., H. Kaube, and V. Limmroth, A practical guide to the management and prevention of migraine. Drugs, 1998. 56(5): p. 811-24.

72. Diener, H.C. and H. Kaube, [Migraine: epidemiology, clinical aspects and diagnosis]. Dtsch Med Wochenschr, 1998. 123(47): p. 1417-8.

73. Kaube, H. and H.C. Diener, [Differential diagnosis of acute migraine attacks]. Med Klin (Munich), 1997. 92(3): p. 145-6.

74. Diener, H.C., et al., Emerging treatments in headache. Eur Neurol, 1997. 38(3): p. 167-74.

75. Kaube, H. and V. Limmroth, [Animal models and their results in relation to the therapy of migraine]. Schmerz, 1996. 10(3): p. 114-20.

76. Hoskin, K.L., H. Kaube, and P.J. Goadsby, Central activation of the trigeminovascular pathway in the cat is inhibited by dihydroergotamine. A c-Fos and electrophysiological study. Brain, 1996. 119 ( Pt 1): p. 249-56.

77. Hoskin, K.L., H. Kaube, and P.J. Goadsby, Sumatriptan can inhibit trigeminal afferents by an exclusively neural mechanism. Brain, 1996. 119 ( Pt 5): p. 1419-28.

78. Weiller, C., et al., Brain stem activation in spontaneous human migraine attacks. Nat Med, 1995. 1(7): p. 658-60.

79. Kaube, H., A. May, and V. Pfaffenrath, Sumatriptan. BMJ, 1994. 308(6943): p. 1573-4.

80. Kaube, H., K.L. Hoskin, and P.J. Goadsby, Lignocaine and headache: an electrophysiological study in the cat with supporting clinical observations in man. J Neurol, 1994. 241(7): p. 415-20.

81. Kaube, H. and P.J. Goadsby, Anti-migraine compounds fail to modulate the propagation of cortical spreading depression in the cat. Eur Neurol, 1994. 34(1): p. 30-5.

82. Kaube, H., et al., Expression of c-Fos-like immunoreactivity in the caudal medulla and upper cervical spinal cord following stimulation of the superior sagittal sinus in the cat. Brain Res, 1993. 629(1): p. 95-102.

83. Kaube, H., K.L. Hoskin, and P.J. Goadsby, Inhibition by sumatriptan of central trigeminal neurones only after blood-brain barrier disruption. Br J Pharmacol, 1993. 109(3): p. 788-92.

84. Kaube, H., K.L. Hoskin, and P.J. Goadsby, Intravenous acetylsalicylic acid inhibits central trigeminal neurons in the dorsal horn of the upper cervical spinal cord in the cat. Headache, 1993. 33(10): p. 541-4.

85. Kaube, H., K.L. Hoskin, and P.J. Goadsby, Activation of the trigeminovascular system by mechanical distension of the superior sagittal sinus in the cat. Cephalalgia, 1992. 12(3): p. 133-6.

86. Goadsby, P.J., H. Kaube, and K.L. Hoskin, Nitric oxide synthesis couples cerebral blood flow and metabolism. Brain Res, 1992. 595(1): p. 167-70.

87. Pfaffenrath, V., et al., Cerebrovascular risk factors in migraine with prolonged aura and without aura. Cephalalgia, 1991. 11(6): p. 257-61.

88. Pfaffenrath, V., et al., MMPI personality profiles in patients with primary headache syndromes. Cephalalgia, 1991. 11(6): p. 263-8.

89. Kaube, H. and E. Biemer, [Results of sex change operations in 30 transsexual patients: psychosocial and sexual adaptation--surgical complications]. Handchir Mikrochir Plast Chir, 1991. 23(5): p. 276-8.

90. Pfaffenrath, V. and H. Kaube, Diagnostics of cervicogenic headache. Funct Neurol, 1990. 5(2): p. 159-64.